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KMID : 1142020180530030227
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Blood Research
2018 Volume.53 No. 3 p.227 ~ p.232
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The incidence of venous thromboembolism is not lowin Korean patients with advanced pancreatic cancer
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Yoon Seug-Yun
Lee Min-Young
Yoon Jina
Kim Han-Jo
Kim Kyoung-Ha
Kim Se-Hyung
Lee Sang-Cheol
Bae Sang-Byung
Kim Chan-Kyu
Lee Nam-Su
Lee Kyu-Taek
Park Sung-Kyu
Hong Dae-Sik
Won Jong-Ho
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Abstract
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Background: Pancreatic cancer is among the most common malignancies associated with venous thromboembolism (VTE). Asian patients are known to have a lower incidence of VTE compared to Caucasian patients. However, few studies have investigated the incidence of VTE in Asian patients with pancreatic cancer.
Methods: This retrospective review of medical records was performed on 505 patients with histopathologically proven advanced stage pancreatic cancer, from January 2006 to December 2012, at Soonchunhyang University Hospitals.
Results: Ninety-four patients (18.6%) had at least one pulmonary embolism (PE), deep vein thrombosis (DVT), or splanchnic vein thrombosis (SVT); 38 patients had isolated SVT; and 56 patients (11.1%) had at least one classic VTE (PE and/or DVT of lower extremities). Patients with more advanced stages of pancreatic cancer (distant metastatic stage, recurrence) or who had received chemotherapy had a higher incidence of classic VTE. Patients who were simultaneously diagnosed with pancreatic cancer and classic VTE had a poorer prognosis than patients with subsequent VTEs. There was a significant difference in overall survival (OS) between the presence and absence of a concurrent classic VTE diagnosis (median: OS, 2.1 mo vs. 10.7 mo; P<0.001). Even when VTE included SVT, the result was similar (P<0.001).
Conclusion: In Korean patients with advanced pancreatic cancer, the incidence of VTEs is comparable to that of Caucasian patients. We also found that pancreatic cancer patients with concurrent VTEs had a poor prognosis compared to patients who developed VTEs later.
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KEYWORD
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Korean, Advanced pancreatic cancer, Venous thromboembolism
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